Five people close to the actor have been arrested and charged in connection with his tragic death (Picture: Brian Ach/Invision/AP)

Matthew Perry’s devastating final words have been revealed as five people have been charged in connection with his death.

The Friends actor passed away in October aged 54 from drowning and the ‘acute effects’ of horse tranquiliser ketamine.

A police investigation into what led to his death is ongoing, with five people – including two doctors, a woman dubbed ‘the ketamine queen’ and the late star’s personal assistant – being charged.

Perry’s former long-term live-in assistant has said Perry told him on the night of his death to ‘shoot me up with a big one’.

He also admitted in court documents he injected the star with three doses of the drug in his final hours.

Kenneth Iwamasa, 59, made the confession in a set of plea agreement papers he signed after he and four others were arrested in connection with supplying the drugs that killed the actor.

The Friends actor died in October (Picture: David M. Benett/Dave Benett/Getty Images)
His former assistant Kenneth Iwamasa has revealed the actor’s final words (Picture: David Hume Kennerly/Getty Images)

The papers show the injections were administered by non-medically trained Iwamasa from 8.30am on the day Matthew died in the hot tub of his Pacific Palisades mansion in Los Angeles.

After the first dose, the papers say Perry’s assistant gave him another one four hours later. He then reportedly gave him another 40 minutes later.

It was before the third injection Perry allegedly told him: ‘Shoot me up with a big one.’

The actor is said to have then told Iwamasa to start up the hot tub where his assistant later found him dead with his head in the water after his employee went to run a set of errands.

Perry’s final words were revealed as his stepfather Keith Morrison spoke out to say he hopes ‘unscrupulous suppliers of dangerous drugs will get the message’ after five people were arrested in connection with the late actor’s death.

Perry is best known for starring as Chandler Bing in the world-renowned sitcom Friends (Picture: NBCU Photo Bank/NBCUniversal via Getty Images)
Perry’s stepfather Keith Morrison has said we ‘look forward to justice’ in the star’s death (Picture: Ryan Young for The Washington Post via Getty Images)

In a statement issued to Entertainment Weekly, he said: ‘We were and still are heartbroken by Matthew’s death, but it has helped to know law enforcement has taken his case very seriously.

‘We look forward to justice taking its course and we’re grateful for the exceptional work of the multiple agencies whose agents investigated Matthew’s death.’

He added: ‘We’re hoping unscrupulous suppliers of dangerous drugs will get the message.’

Perry’s doctors have also been accused of abusing their ‘position of trust’, with DEA Administrator Anne Milgram commenting about the case: ‘Matthew Perry’s journey began with unscrupulous doctors who abused their position of trust because they saw him as a payday, to street dealers who gave him ketamine in unmarked vials.

‘Every day, the DEA works tirelessly with our federal, state, and local partners to protect the public and to hold accountable those that distribute deadly and dangerous drugs – whether they are local drug traffickers or doctors who violate their sworn oath to care for patients.’

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